Article
SPACe: an open-source, single-cell analysis of Cell Painting data.
Nature communications - 23 Nov 2024
Stossi Fabio, Singh Pankaj K, Marini Michela, Safari Kazem, Szafran Adam T, Rivera Tostado Alejandra, Candler Christopher D, Mancini Maureen G, Mosa Elina A, Bolt Michael J, Labate Demetrio, Mancini Michael A
Abstract excerpt
Phenotypic profiling by high throughput microscopy, including Cell Painting, has become a leading tool for screening large sets of perturbations in cellular models. To efficiently analyze this big data, available open-source software requires computational resources usually not available to most laboratories. In addition, the cell-to-cell variation of responses within a population, while collected and analyzed,...
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