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Article

Essential thrombocythaemia progression to the fibrotic phase is associated with a decrease in JAK2 and PDL1 levels.

Annals of hematology - 1 Dec 2022

Lewandowski Krzysztof, Kanduła Zuzanna, Gniot Michał, Paczkowska Edyta, Nawrocka Paulina Maria, Wojtaszewska Marzena, Janowski Michał, Mariak Magdalena, Handschuh Luiza, Kozlowski Piotr

Abstract excerpt

It has been postulated that the changes in the molecular characteristics of the malignant clone(s) and the abnormal activation of JAK-STAT signaling are responsible for myeloproliferative neoplasm progression to more advanced disease phases and the immune escape of the malignant clone. The continuous JAK-STAT pathway activation leads to enhanced activity of the promoter of CD274 coding programmed death-1 receptor...

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Identifiers

PMID: 36266510
DOI: 10.1007/s00277-022-05001-8
PMCID: PMC9646550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Essential thrombocythaemia progression to the fibrotic phase is associated with a decrease in JAK2 and PDL1 levels.PMID 36266510Read ↗

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