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PD-L1 and JAK2 mRNA level in essential thrombocythaemia depends on the driver mutational status and the bone marrow fibrosis grade

2022-02-17

Abstract excerpt

<h4>Background: </h4> JAK-STAT pathway activation leads to an enhanced activity of the promoter of CD274 ( PDL1 ) coding programmed death-1 receptor ligand (PD-L1), increased PD-L1 level and the immune escape of myeloproliferative neoplasms (MPN) cells. It has been postulated that the bone marrow failure, bone marrow myeloid metaplasia, and changes in the molecular characteristics of the malignant clone(s) during...

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Literature Corpus work
32150b83-e02f-54a0-9bd8-2eda325a7529
DOI
10.21203/rs.3.rs-1347762/v1
Open publication

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PD-L1 and JAK2 mRNA level in essential thrombocythaemia depends on the driver mutational status and the bone marrow fibrosis gradeDOI 10.21203/rs.3.rs-1347762/v1
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