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Article

Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis.

Journal of hematology & oncology - 2 Feb 2012

Tognon Raquel, Gasparotto Elainy P L, Neves Renata P, Nunes Natália S, Ferreira Aline F, Palma Patrícia V B, Kashima Simone, Covas Dimas T, Santana Mary, Souto Elizabeth X, Zanichelli Maria Aparecida, Simões Belinda P, de Souza Ana Maria, Castro Fabíola A

Abstract excerpt

BACKGROUND: Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. The JAK2 V617F mutation and PRV1 gene overexpression may contribute to MPN physiopathology. We hypothesized that deregulation of the apoptotic machinery may also play a role in the pathogenesis of...

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Identifiers

PMID: 22300941
DOI: 10.1186/1756-8722-5-2
PMCID: PMC3298534

Genes

JAK2
BAX
BCL2
BID
BIK
BAD
MCL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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