Comparison of JAK2V617F -positive essential thrombocythaemia and early primary myelofibrosis: The impact of mutation burden and histology.

doi:10.1002/hon.2430

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Article

Comparison of JAK2V617F -positive essential thrombocythaemia and early primary myelofibrosis: The impact of mutation burden and histology.

Hematological oncology - 1 Feb 2018

Latagliata Roberto, Polverelli Nicola, Tieghi Alessia, Palumbo Giuseppe Alberto, Breccia Massimo, Sabattini Elena, Villari Loredana, Riminucci Mara, Valli Riccardo, Catani Lucia, Alimena Giuliana, Ottaviani Emanuela, Fama Angelo, Martinelli Giovanni, Perricone Margherita, Spinsanti Marco, Cavo Michele, Vianelli Nicola, Palandri Francesca

Abstract excerpt

An accurate histological diagnosis may distinguish essential thrombocythaemia (ET) from early primary myelofibrosis (early-PMF), which is associated with worse outcome. Outcome of ET is also negatively affected by the presence of the JAK2V617F mutation. To investigate the impact of JAK2V617F mutation burden and histology on outcome, we collected 475 WHO-diagnosed ET (69.2%) or early-PMF JAK2V617F -positive...

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PMID: 28509339
DOI: 10.1002/hon.2430

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