Article
Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5.
Human cell - 1 Oct 2020
Guru Sameer Ahamd, Sumi Mamta P, Mir Rashid, Waza Ajaz Ahmad, Bhat Musadiq Ahmad, Zuberi Mariyam, Lali Promod, Saxena Alpana
Abstract excerpt
Escalated PD-L1 expression has been identified during malignant transformation in a number of cancer types and helps cancer cells escape an effective anti-tumor immune response. The mechanisms underlying escalated production of PD-L1 in many cancers, however, are still far from clear. We studied PD-L1, STAT3 and STAT5 mRNA expression using qRT-PCR in 72 BCR/ABL1 negative myeloproliferative neoplasm (MPN) patients...
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