Article
The gain-of-function JAK2 V617F mutation shifts the phenotype of essential thrombocythemia and chronic idiopathic myelofibrosis to more "erythremic" and less "thrombocythemic": a molecular, histologic, and clinical study.
International journal of hematology - 1 Aug 2007
Rudzki Zbigniew, Sacha Tomasz, Stój Anastazja, Czekalska Sylwia, Wójcik Małgorzata, Skotnicki Aleksander B, Grabowska Barbara, Zduńczyk Andrzej, Okoń Krzysztof, Stachura Jerzy
Abstract excerpt
We investigated the prevalence of the JAK2 V617F gain-of-function mutation in patients with Philadelphia chromosome-negative chronic myeloproliferative disorders (Ph- MPD) and explored the links between JAK2 mutational status and the clinicopathologic picture of essential thrombocythemia (ET), ch...
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