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Article

Distinct patterns of cytogenetic and clinical progression in chronic myeloproliferative neoplasms with or without JAK2 or MPL mutations.

Cancer genetics and cytogenetics - 1 Feb 2010

Millecker Laura, Lennon Patrick A, Verstovsek Srdan, Barkoh Bedia, Galbincea John, Hu Peter, Chen Su S, Jones Dan

Abstract excerpt

Chronic myeloproliferative neoplasms (MPN), including essential thrombocythemia (ET) and primary myelofibrosis (PMF), result from interactions between initiating growth factor mutations and secondary genomic changes. Codon 617 mutation of the JAK2 kinase is found in 40-50% of ET/PMF, whereas the...

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Source

Identifiers

PMID: 20113830
DOI: 10.1016/j.cancergencyto.2009.10.014

Genes

JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20113830-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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