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Viral transduction of primary human lymphoma B cells reveals mechanisms of NOTCH-mediated immune escape

20 Oct 2022

Abstract excerpt

Abstract Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells from patients with Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL), differing only in their expression of the intracellular domain (ICD) of NOTCH1 or NOTCH2. Our...

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PMID: 36266281
DOI: 10.1038/s41467-022-33739-2

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