Article

MYC Functions as a Switch for Natural Killer Cell-Mediated Immune Surveillance of Lymphoid Malignancies

2018-12-28

Abstract excerpt

The MYC oncogene drives T and B lymphoid malignancies, including Burkitt’s lymphoma (BL) and Acute Lymphoblastic Leukemia (ALL). Using CyTOF, we demonstrate a systemic reduction in natural killer (NK) cell-mediated surveillance in SRα-tTA/Tet-O-MYC ON mice bearing MYC-driven T-lymphomas, due to an arrest in NK cell maturation. Inactivation of lymphoma-intrinsic MYC releases the brakes on NK maturation restoring N...

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Literature Corpus work: 2384a18e-3077-5dec-aa75-ccf1b37ca5ff
DOI: 10.1101/503086

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