Article

Spontaneous EBV-positive B cell line from rectal tumor: characterization, interaction with autologous tumor-infiltrating T lymphocytes, comparison with B lymphoma cell lines

2025-06-23

Abstract excerpt

<title>Abstract</title> <p>Recent studies underscore herpesvirus-associated risks, especially HHV6 and Epstein–Barr virus (EBV), in CAR-T and tumor-infiltrating lymphocyte (TIL) therapies, partly due to ex vivo cell manipulation. EBV-driven B cell outgrowth can occur during TIL expansion, and EBV-transformed B cells may exert immunomodulatory functions, potentially impacting TIL therapy efficacy — areas that rema...

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Literature Corpus work: f65b79b0-1837-573e-8743-f4da502a49b2
DOI: 10.21203/rs.3.rs-6835907/v1

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