Article
Common nonmutational NOTCH1 activation in chronic lymphocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 4 Apr 2017
Fabbri Giulia, Holmes Antony B, Viganotti Mara, Scuoppo Claudio, Belver Laura, Herranz Daniel, Yan Xiao-Jie, Kieso Yasmine, Rossi Davide, Gaidano Gianluca, Chiorazzi Nicholas, Ferrando Adolfo A, Dalla-Favera Riccardo
Abstract excerpt
Activating mutations of NOTCH1 (a well-known oncogene in T-cell acute lymphoblastic leukemia) are present in ∼4-13% of chronic lymphocytic leukemia (CLL) cases, where they are associated with disease progression and chemorefractoriness. However, the specific role of NOTCH1 in leukemogenesis remains to be established. Here, we report that the active intracellular portion of NOTCH1 (ICN1) is detectable in ∼50% of...
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