Article

NOTCH1 drives immune-escape mechanisms in B cell malignancies

2021-04-11

Abstract excerpt

NOTCH1 is a recurrently mutated gene in Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL). Functional studies to investigate its role have been hampered by the inability to genetically manipulate primary human lymphoma cells, attributed to low transduction-efficacy and procedure-associated toxicity. To overcome these limitations, we have developed a novel method to retrovirally transfer genes into...

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Literature Corpus work: 785b862c-bd41-59c3-a069-6e26a884ebf9
DOI: 10.1101/2021.04.10.439192

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