Article
Genome-wide identification of allele-specific effects on gene expression for single and multiple individuals.
Gene - 1 Jan 2014
Zhang Shaojun, Wang Fang, Wang Hongzhi, Zhang Fan, Xu Bin, Li Xia, Wang Yadong
Abstract excerpt
The analysis of allele-specific gene expression (ASE) is essential for the mapping of genetic variants that affect gene regulation, and for the identification of alleles that modify disease risk. Although RNA sequencing offers the opportunity to measure expression at allele levels, the availability of powerful statistical methods for mapping ASE in single or multiple individuals is limited. We developed a maximum...
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