Article
Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues.
BMC genomics - 4 Jul 2018
Xiang Ruidong, Hayes Ben J, Vander Jagt Christy J, MacLeod Iona M, Khansefid Majid, Bowman Phil J, Yuan Zehu, Prowse-Wilkins Claire P, Reich Coralie M, Mason Brett A, Garner Josie B, Marett Leah C, Chen Yizhou, Bolormaa Sunduimijid, Daetwyler Hans D, Chamberlain Amanda J, Goddard Michael E
Abstract excerpt
BACKGROUND: Mammalian phenotypes are shaped by numerous genome variants, many of which may regulate gene transcription or RNA splicing. To identify variants with regulatory functions in cattle, an important economic and model species, we used sequence variants to map a type of expression quantitative trait loci (expression QTLs) that are associated with variations in the RNA splicing, i.e., sQTLs. To further the...
Topics
- Animals
- Blood Cells
- Caseins
- Cattle
- Exons
- Female
- Genetic Variation
- Liver
- Mammary Glands, Animal
- Muscles