Article
The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats.
Nucleic acids research - 28 Oct 2022
Munro Daniel, Wang Tengfei, Chitre Apurva S, Polesskaya Oksana, Ehsan Nava, Gao Jianjun, Gusev Alexander, Woods Leah C Solberg, Saba Laura M, Chen Hao, Palmer Abraham A, Mohammadi Pejman
Abstract excerpt
Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological traits. Mapping Quantitative Trait Loci (QTL) associated with transcriptional changes would help to identify mechanisms underlying these traits. We generated genotype and transcriptome data for five brain regions from 88 HS rats. We identified 21 392 cis-QTLs...
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