Article
Genetic basis of transcriptome differences between the founder strains of the rat HXB/BXH recombinant inbred panel.
Genome biology - 27 Apr 2012
Simonis Marieke, Atanur Santosh S, Linsen Sam, Guryev Victor, Ruzius Frans-Paul, Game Laurence, Lansu Nico, de Bruijn Ewart, van Heesch Sebastiaan, Jones Steven J M, Pravenec Michal, Aitman Tim J, Cuppen Edwin
Abstract excerpt
BACKGROUND: With the advent of next generation sequencing it has become possible to detect genomic variation on a large scale. However, predicting which genomic variants are damaging to gene function remains a challenge, as knowledge of the effects of genomic variation on gene expression is still limited. Recombinant inbred panels are powerful tools to study the cis and trans effects of genetic variation on...
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