Article
Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale.
PLoS biology - 1 Sept 2024
Hoang Nhung, Sardaripour Neda, Ramey Grace D, Schilling Kurt, Liao Emily, Chen Yiting, Park Jee Hyun, Bledsoe Xavier, Landman Bennett A, Gamazon Eric R, Benton Mary Lauren, Capra John A, Rubinov Mikail
Abstract excerpt
An understanding of human brain individuality requires the integration of data on brain organization across people and brain regions, molecular and systems scales, as well as healthy and clinical states. Here, we help advance this understanding by leveraging methods from computational genomics to integrate large-scale genomic, transcriptomic, neuroimaging, and electronic-health record data sets. We estimated...
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