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Article

Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons

18 Oct 2022

Abstract excerpt

Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD pathophysiology can guide the discovery of therapeutics to slow the disease progression. However, insights from human postmortem brain studies only portray the latter stages of PD, and there is a lack of data surrounding molecular events...

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PMID: 36258029
DOI: 10.1038/s41531-022-00400-0

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