Article
A simple approach for detecting HLA-A*02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting.
HLA - 1 Jan 2023
Witt Johannes, Haupt Saskia, Ahadova Aysel, Bohaumilitzky Lena, Fuchs Vera, Ballhausen Alexej, Przybilla Moritz Jakob, Jendrusch Michael, Seppälä Toni T, Fürst Daniel, Walle Thomas, Busch Elena, Haag Georg Martin, Hüneburg Robert, Nattermann Jacob, von Knebel Doeberitz Magnus, Heuveline Vincent, Kloor Matthias
Abstract excerpt
The HLA system represents a central component of the antigen presentation machinery. As every patient possesses a defined set of HLA molecules, only certain antigens can be presented on the cell surface. Thus, studying HLA type-dependent antigen presentation can improve the understanding of variation in susceptibility to various diseases, including infectious diseases and cancer. In archival formalin-fixed...
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