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ATF4-dependent fructolysis fuels growth of glioblastoma multiforme

16 Oct 2022

Abstract excerpt

Excessive consumption of fructose in the Western diet contributes to cancer development. However, it is still unclear how cancer cells coordinate glucose and fructose metabolism during tumor malignant progression. We demonstrate here that glioblastoma multiforme (GBM) cells switch their energy supply from glycolysis to fructolysis in response to glucose deprivation. Mechanistically, glucose deprivation induces...

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PMID: 36245009
DOI: 10.1038/s41467-022-33859-9

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