GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase

Abstract excerpt

Abstract Background Fructose is an abundant source of carbon and energy for cells to use for metabolism, but only certain cell types use fructose to proliferate. Tumor cells that acquire the ability to metabolize fructose have a fitness advantage over their neighboring cells, but the proteins that mediate fructose metabolism in this context are unknown. Here, we investigated the determinants of fructose-mediated...

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