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Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions.

Scientific reports - 28 May 2025

Rushin Anna, Shaikh Aleezeh, Hardin Callie, Deleyrolle Loic P, Merritt Matthew E

Abstract excerpt

Glioblastomas (GBM) are the most prevalent primary brain tumors, affecting 5 in every 100,000 people. GBMs optimize proliferation through adaptive cellular metabolism, frequently exploiting the Warburg effect by increasing aerobic glycolysis and glucose utilization to facilitate rapid cell growth. This disproportionate reliance on glucose has driven interest in using the ketogenic diet (KD) as a treatment for...

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Identifiers

PMID: 40436928
DOI: 10.1038/s41598-025-02124-6
PMCID: PMC12120007

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