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Article

The microphthalmia-associated transcription factor is involved in gastrointestinal stromal tumor growth.

Cancer gene therapy - 1 Feb 2023

Proaño-Pérez Elizabeth, Serrano-Candelas Eva, García-Valverde Alfonso, Rosell Jordi, Gómez-Peregrina David, Navinés-Ferrer Arnau, Guerrero Mario, Serrano César, Martín Margarita

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common neoplasms of mesenchymal origin, and most of them emerge due to the oncogenic activation of KIT or PDGFRA receptors. Despite their relevance in GIST oncogenesis, critical intermediates mediating the KIT/PDGFRA transforming program remain mostly unknown. Previously, we found that the adaptor molecule SH3BP2 was involved in GIST cell survival, likely due...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36241703
DOI: 10.1038/s41417-022-00539-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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