Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.

Immunology and allergy clinics of North America - 1 May 2014

Cruse Glenn, Metcalfe Dean D, Olivera Ana

Abstract excerpt

In this review, the authors discuss common gain-of-function mutations in the stem cell factor receptor KIT found in mast cell proliferation disorders and summarize the current understanding of the molecular mechanisms by which these transforming mutations may affect KIT structure and function leading to altered downstream signaling and cellular transformation. Drugs targeting KIT have shown mixed success in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Hematologic Neoplasms
Share to Mast Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mastocytosis

Share to Protein Kinase Inhibitors

Share to Protein Transport

Share to Proto-Oncogene Proteins c-kit

Share to Stem Cell Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 24745671
DOI: 10.1016/j.iac.2014.01.002
PMCID: PMC3994404

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.PMID 24745671Read ↗

Recent advances in the understanding of mastocytosis: the role of KIT mutations.Semantic proximity Read ↗

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disordersSemantic proximity Read ↗

<i>KIT</i> and MastocytosisSemantic proximity Read ↗

Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression.Semantic proximity Read ↗

Molecular defects in mastocytosis: KIT and beyond KIT.Semantic proximity Read ↗

Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder.Semantic proximity Read ↗

Normal and oncogenic forms of the receptor tyrosine kinase kit.Semantic proximity Read ↗

Stem Cell Factor Receptor/c-Kit: From Basic Science to Clinical ImplicationsSemantic proximity Read ↗

Targeting c-Kit mutations: basic science to novel therapies.Semantic proximity Read ↗

c-Kit and c-kit mutations in mastocytosis and other hematological diseasesSemantic proximity Read ↗

C-KIT signaling in cancer treatment.Semantic proximity Read ↗

Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.