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Article

The adaptor 3BP2 is required for KIT receptor expression and human mast cell survival.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2015

Ainsua-Enrich Erola, Serrano-Candelas Eva, Álvarez-Errico Damiana, Picado César, Sayós Joan, Rivera Juan, Martín Margarita

Abstract excerpt

SH3-binding protein 2 (3BP2) is a cytoplasmic adaptor protein that acts as a positive regulator in mast cell FcεRI-dependent signaling. The KIT receptor whose ligand is the stem cell factor is necessary for mast cell development, proliferation, and survival as well as for optimal IgE-dependent si...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Silencing

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Share to Microphthalmia-Associated Transcription Factor

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 25810396
DOI: 10.4049/jimmunol.1402887
PMCID: PMC4402263

Genes

KIT
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25810396-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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