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Biology and Clinical Relevance of the Micropthalmia Family of Transcription Factors in Human Cancer

14 Jun 2011

Abstract excerpt

Members of the micropthalmia (MiT) family of transcription factors (MITF, TFE3, TFEB, and TFEC) are physiologic regulators of cell growth, differentiation, and survival in several tissue types. Because their dysregulation can lead to melanoma, renal cell carcinoma, and some sarcomas, understanding why these genes are co-opted in carcinogenesis may be of general utility. Here we describe the structure of the MiT...

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Identifiers

PMID: 21670463
DOI: 10.1200/jco.2010.32.6223

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