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Article

MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2011

Kim Won Kyu, Park Misun, Kim Young-Kook, Tae You Kwon, Yang Han-Kwang, Lee Jae Myun, Kim Hoguen

Abstract excerpt

PURPOSE: Gain-of-function mutations and KIT overexpression are well-known tumorigenesis mechanisms in gastrointestinal stromal tumors (GIST). This study aimed to discover microRNAs (miRNA) that target KIT and reveal the relationship between the discovered miRNAs and KIT expression in GISTs. EXPERIMENTAL DESIGN: Fresh-frozen GISTs from 31 patients were used to confirm the relationship between miR-494 and KIT...

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Identifiers

PMID: 22042971
DOI: 10.1158/1078-0432.CCR-11-0166

Genes

KIT
STAT3

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