Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis.

Oncotarget - 30 Nov 2014

Li Chien-Feng, Chen Li-Tzong, Lan Jui, Chou Fong-Fu, Lin Ching-Yih, Chen Yen-Yang, Chen Tzu-Ju, Li Shau-Hsuan, Yu Shih-Chen, Fang Fu-Ming, Tai Hui-Chun, Huang Hsuan-Ying

Abstract excerpt

Non-random gains of chromosome 5p have been observed in clinically aggressive gastrointestinal stromal tumors, whereas the driving oncogenes on 5p remain to be characterized. We used an integrative genomic and functional approach to identify amplified oncogenes on 5p and to evaluate the relevance of AMACR amplification at 5p13.3 and its overexpression in gastrointestinal stromal tumors. Thirty-seven tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azoles
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase 4

Share to Cyclin E

Share to G1 Phase

Share to Gastrointestinal Stromal Tumors

Share to Oncogene Proteins

Share to Racemases and Epimerases

Source

Open in PubMed Open full text

Identifiers

PMID: 25473890
DOI: 10.18632/oncotarget.2597
PMCID: PMC4294386

Genes

AMACR
CDK4
KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis.PMID 25473890Read ↗

Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors.Semantic proximity Read ↗

Genomic and transcriptomic landscape of human gastrointestinal stromal tumors.Semantic proximity Read ↗

High density DNA array analysis reveals distinct genomic profiles in a subset of gastrointestinal stromal tumors.Semantic proximity Read ↗

Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumorsSemantic proximity Read ↗

Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS).Semantic proximity Read ↗

Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)Semantic proximity Read ↗

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.Semantic proximity Read ↗

Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and OncogenesisSemantic proximity Read ↗

KITlow Cells Mediate Imatinib Resistance in Gastrointestinal Stromal TumorSemantic proximity Read ↗

Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors.Semantic proximity Read ↗

Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal TumorsSemantic proximity Read ↗

Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.