Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

doi:10.1053/j.gastro.2015.04.006

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Article

Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.

Gastroenterology - 1 Aug 2015

Hayashi Yujiro, Bardsley Michael R, Toyomasu Yoshitaka, Milosavljevic Srdjan, Gajdos Gabriella B, Choi Kyoung Moo, Reid-Lombardo K Marie, Kendrick Michael L, Bingener-Casey Juliane, Tang Chih-Min, Sicklick Jason K, Gibbons Simon J, Farrugia Gianrico, Taguchi Takahiro, Gupta Anu, Rubin Brian P, Fletcher Jonathan A, Ramachandran Abhijit, Ordog Tamas

Abstract excerpt

BACKGROUND & AIMS: In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is predominantly expressed by interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor-α (PDGFRA) polypeptide is expressed by so-called fibroblast-like cells. KIT and PDGFRA have been reported to be coexpressed in ICC precursors and gastrointestinal stromal tumors (GISTs), which...

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Identifiers

PMID: 25865047
DOI: 10.1053/j.gastro.2015.04.006
PMCID: PMC4516576

Genes

KIT
PDGFRA
ETV1
PDGFRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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