Article
Optimization and Identification of Single Mutation in Hemoglobin Variants with 2,2,2 Trifluoroethanol Modified Digestion Method and Nano-LC Coupled MALDI MS/MS.
Molecules (Basel, Switzerland) - 26 Sept 2022
Dasauni Pushpanjali, Singh Nirpendra, Chhabra Varun, Mahapatra Manoranjan, Saxena Renu, Kundu Suman
Abstract excerpt
Background: Hemoglobin (Hb) variants arise due to point mutations in globin chains and their pathological treatments rely heavily on the identification of the nature and location of the mutation in the globin chains. Traditional methods for diagnosis such as HPLC and electrophoresis have their own limitations. Therefore, the present study aims to develop and optimize a specific method of sample processing that...
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