Article
Hemoglobin variant analysis of whole blood and dried blood spots by MS.
Bioanalysis - 1 Aug 2013
Edwards Rebecca L, Martin Nicholas J, Cooper Helen J
Abstract excerpt
MS allows for the unequivocal diagnosis of hemoglobin variants, or hemoglobinopathies. Hemoglobinopathies are the most common inherited disorder and there is a need for rapid detection of clinically significant variants, such as sickle hemoglobin, which is responsible for sickle cell disease. In this review, we describe the development of MS approaches for the determination of hemoglobin variants from both whole...
Topics
- Dried Blood Spot Testing
- Genetic Variation
- Hemoglobins
- Humans
- Mass Spectrometry