Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular dynamics simulation study on the structures of fascin mutants.

Journal of molecular recognition : JMR - 1 Jan 2023

Wu Xiaodong, Xu Li-Yan, Li En-Min, Dong Geng

Abstract excerpt

Fascin is a filamentous actin (F-actin) bundling protein, which cross-links F-actin into bundles and becomes an important component of filopodia on the cell surface. Fascin is overexpressed in many types of cancers. The mutation of fascin affects its ability to bind to F-actin and the progress of cancer. In this paper, we have studied the effects of residues of K22, K41, K43, K241, K358, K399, and K471 using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Actins
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Pseudopodia

Source

Identifiers

PMID: 36225126
DOI: 10.1002/jmr.2998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular dynamics simulation study on the structures of fascin mutants.PMID 36225126Read ↗

New insights into the function of Fascin in actin bundling: A combined theoretical and experimental study.Semantic proximity Read ↗

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.Semantic proximity Read ↗

Fascin promotes filopodia formation independent of its role in actin bundlingSemantic proximity Read ↗

Mechanism of actin filament bundling by fascin.Semantic proximity Read ↗

Structural mechanism underlying regulation of human EFhd2/Swiprosin-1 actin-bundling activity by Ser183 phosphorylation.Semantic proximity Read ↗

Intrinsic dynamic behavior of fascin in filopodia.Semantic proximity Read ↗

Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants.Semantic proximity Read ↗

Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface.Semantic proximity Read ↗

Expression of the Actin-Bundling Protein Fascin in Cultured Human Dendritic Cells Correlates with Dendritic Morphology and Cell DifferentiationSemantic proximity Read ↗

Effect of amino acid mutations on intra-dimer tubulin-tubulin binding strength of microtubules.Semantic proximity Read ↗

Molecular dynamics simulations of wild type and mutants of botulinum neurotoxin A complexed with synaptic vesicle protein 2C.Semantic proximity Read ↗

Dynamic Regulation of α-Actinin's Calponin Homology Domains on F-Actin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.