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Article

Mechanism of actin filament bundling by fascin.

The Journal of biological chemistry - 26 Aug 2011

Jansen Silvia, Collins Agnieszka, Yang Changsong, Rebowski Grzegorz, Svitkina Tatyana, Dominguez Roberto

Abstract excerpt

Fascin is the main actin filament bundling protein in filopodia. Because of the important role filopodia play in cell migration, fascin is emerging as a major target for cancer drug discovery. However, an understanding of the mechanism of bundle formation by fascin is critically lacking. Fascin consists of four β-trefoil domains. Here, we show that fascin contains two major actin-binding sites, coinciding with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21685497
DOI: 10.1074/jbc.M111.251439
PMCID: PMC3191048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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