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Article

Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.

Journal of molecular biology - 27 Apr 2018

Huang Jianyun, Dey Raja, Wang Yufeng, Jakoncic Jean, Kurinov Igor, Huang Xin-Yun

Abstract excerpt

Tumor metastasis is responsible for ~90% of all cancer deaths. One of the key steps of tumor metastasis is tumor cell migration and invasion. Filopodia are cell surface extensions that are critical for tumor cell migration. Fascin protein is the main actin-bundling protein in filopodia. Small-molecule fascin inhibitors block tumor cell migration, invasion, and metastasis. Here we present the structural basis for...

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Identifiers

PMID: 29573988
DOI: 10.1016/j.jmb.2018.03.009
PMCID: PMC5916032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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