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Article

New insights into the function of Fascin in actin bundling: A combined theoretical and experimental study.

The international journal of biochemistry & cell biology - 1 Oct 2021

Wu Xiaodong, Wen Bing, Lin Lirui, Shi Wenqi, Li Dajia, Cheng Yinwei, Xu Li-Yan, Li En-Min, Dong Geng

Abstract excerpt

Fascin, one of actin bundling proteins, plays an important role in the cross-linking of actin filaments (F-actin). Phosphorylation of Fascin is an important posttranslational modification to affect its structure and function. For example, a phosphomimetic mutation of Fascin-S39D decrease its bundling ability with F-actin significantly. In this paper, we studied the actin-bundling activity of Fascin by using...

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Identifiers

PMID: 34390855
DOI: 10.1016/j.biocel.2021.106056

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