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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer.

Cell metabolism - 6 Aug 2024

Zhu Min, Wang Yunguan, Lu Tianshi, Guo Jason, Li Lin, Hsieh Meng-Hsiung, Gopal Purva, Han Yi, Fujiwara Naoto, Wallace Darren P, Yu Alan S L, Fang Xiangyi, Ransom Crystal, Verschleisser Sara, Hsiehchen David, Hoshida Yujin, Singal Amit G, Yopp Adam, Wang Tao, Zhu Hao

Abstract excerpt

Somatic mutations in non-malignant tissues are selected for because they confer increased clonal fitness. However, it is uncertain whether these clones can benefit organ health. Here, ultra-deep targeted sequencing of 150 liver samples from 30 chronic liver disease patients revealed recurrent somatic mutations. PKD1 mutations were observed in 30% of patients, whereas they were only detected in 1.3% of...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38901424
DOI: 10.1016/j.cmet.2024.05.015
PMCID: PMC12133308

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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