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Leveraging Patient-Derived Organoids for Personalized Liver Cancer Treatment.

International journal of biological sciences - 1 Jan 2024

Rao Jianhua, Song Chao, Hao Yangyang, Chen Zaozao, Feng Sidu, Xu Shihui, Wu Xiaoyue, Xuan Zhengfeng, Fan Ye, Li Wenzhu, Li Junda, Ren Yong, Li Jian, Cheng Feng, Gu Zhongze

Abstract excerpt

Primary liver cancer (PLC) is a primary cause of cancer-related death worldwide, and novel treatments are needed due to the limited options available for treatment and tumor heterogeneity. 66 surgically removed PLC samples were cultured using the self-developed 2:2 method, and the final success rate for organoid culture was 40.9%. Organoid performance has been evaluated using comprehensive molecular measurements,...

Topics

Humans
Organoids
Liver Neoplasms
Precision Medicine
Male
Female
Middle Aged
Aged
Mutation
Antineoplastic Agents
Adult

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PMID: 39430248
DOI: 10.7150/ijbs.96317
PMCID: PMC11488587

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TP53

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