Article
Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells.
Microbiology spectrum - 21 Dec 2022
Wang Jingjing, Zhang Mengsi, Cui Xiaochun, Gao Xiang, Sun Weifeng, Ge Xinna, Zhang Yongning, Guo Xin, Han Jun, Zhou Lei, Yang Hanchun
Abstract excerpt
Porcine reproductive and respiratory syndrome (PRRS) is a globally important disease threatening the pork industry, and modified live-virus (MLV) vaccines are widely used for its prevention. However, PRRS MLV shows high potential for reversion to virulence, leading to a major concern about its safety. Yet the revertant mechanism is still poorly understood. Here, attenuated virus JXwn06-P80, derived from the...
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