Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic sequencing reveals mutations potentially related to the overattenuation of a highly pathogenic porcine reproductive and respiratory syndrome virus.

Clinical and vaccine immunology : CVI - 1 Apr 2013

Yu Xiuling, Chen Nanhua, Deng Xiaoyu, Cao Zhen, Han Wei, Hu Dongmei, Wu Jiajun, Zhang Shuo, Wang Baoyue, Gu Xiaoxue, Tian Kegong

Abstract excerpt

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) continues to evolve when serially passaged in Marc-145 cells. In this study, we analyzed the genomic and antigenic variants of HP-PRRSV strain JXA1 during in vitro passage. Protective efficacies of JXA1 from passages 100, 110, 120, 140, and 170 against the high-virulence parental virus were evaluated by inoculating pigs with each of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to 5' Untranslated Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Porcine Reproductive and Respiratory Syndrome

Share to Porcine respiratory and reproductive syndrome virus

Share to Serial Passage

Share to Survival Analysis

Share to Viral Nonstructural Proteins

Share to Viral Vaccines

Source

Open in PubMed Open full text

Identifiers

PMID: 23408525
DOI: 10.1128/CVI.00672-12
PMCID: PMC3623411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic sequencing reveals mutations potentially related to the overattenuation of a highly pathogenic porcine reproductive and respiratory syndrome virus.PMID 23408525Read ↗

Genetic variation, pathogenicity, and immunogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus strain XH-GD at different passage levels.Semantic proximity Read ↗

Development of a differentiable virus via a spontaneous deletion in the nsp2 region associated with cell adaptation of porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

Molecular mutations associated with the in vitro passage of virulent porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

Experimental infection and comparative genomic analysis of a highly pathogenic PRRSV-HBR strain at different passage levels.Semantic proximity Read ↗

Mutations in the genome of the highly pathogenic porcine reproductive and respiratory syndrome virus potentially related to attenuation.Semantic proximity Read ↗

A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro.Semantic proximity Read ↗

Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells.Semantic proximity Read ↗

Phenotypic and genotypic analyses of an attenuated porcine reproductive and respiratory syndrome virus strain after serial passages in cultured porcine alveolar macrophages.Semantic proximity Read ↗

Protective efficacy of a candidate attenuated live vaccine derived from an NADC30-like strain against homologous porcine reproductive and respiratory syndrome virus challenge.Semantic proximity Read ↗

Genetic diversity in envelope genes of contemporary U.S. porcine reproductive and respiratory syndrome virus strains influences viral antigenicity.Semantic proximity Read ↗

Attenuation and immunogenicity of a live high pathogenic PRRSV vaccine candidate with a 32-amino acid deletion in the nsp2 protein.Semantic proximity Read ↗

A vaccine revertant of highly pathogenic porcine reproductive and respiratory syndrome virus: re-emergence after lurking for 12 yearsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.