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Experimental infection and comparative genomic analysis of a highly pathogenic PRRSV-HBR strain at different passage levels.

Veterinary microbiology - 25 Oct 2013

Wei Yanwu, Li Shengbin, Huang Liping, Tang Qinghai, Liu Jianbo, Liu Dan, Wang Yiping, Wu Hongli, Liu Changming

Abstract excerpt

A highly pathogenic strain of porcine reproductive and respiratory syndrome virus (PRRSV-HBR) was passaged on Marc-145 cells for 125 passages. In order to elucidate the change in virulence of PRRSV-HBR strain during the process of passage in vitro, swine infection experiment was performed with the viruses of low (F5 and F10) and high passage (F125). In addition, to identify the mutations related to the change in...

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PMID: 23850443
DOI: 10.1016/j.vetmic.2013.05.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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