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Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

26 Aug 2024

Abstract excerpt

Japanese encephalitis virus (JEV) is a zoonotic mosquito-transmitted Flavivirus circulating in birds and pigs. In humans, JEV can cause severe viral encephalitis with high mortality. Considering that vector-free direct virus transmission was observed in experimentally infected pigs, JEV introduction into an immunologically naïve pig population could result in a series of direct transmissions disrupting the...

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PMID: 39186783
DOI: 10.1371/journal.ppat.1012059

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