Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A vaccine revertant of highly pathogenic porcine reproductive and respiratory syndrome virus: re-emergence after lurking for 12 years.

Microbiology spectrum - 1 Jul 2025

Wu Weixin, Lin Lin, Ye Zian, Hou Ruoning, Zhou Qiongqiong, Zhou Lei, Yang Hanchun

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Modified live virus (MLV) vaccines are widely used for PRRSV prevention and control. However, MLV vaccines can still infect hosts and replicate in the target cells, increasing the risk of virus recombination and reversion to virulence. Recently, a highly pathogenic PRRSV strain appeared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Virus-based gene therapy research

Source

Open in PubMed Open full text

Identifiers

PMID: 40401956
DOI: 10.1128/spectrum.00728-25
PMCID: PMC12210977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A vaccine revertant of highly pathogenic porcine reproductive and respiratory syndrome virus: re-emergence after lurking for 12 yearsPMID 40401956Read ↗

Attenuated Porcine Reproductive and Respiratory Syndrome Virus Regains Its Fatal Virulence by Serial Passaging in Pigs or Porcine Alveolar Macrophages To Increase Its Adaptation to Target Cells.Semantic proximity Read ↗

Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and SafetySemantic proximity Read ↗

Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutationsSemantic proximity Read ↗

Commercial PRRS Modified-Live Virus VaccinesSemantic proximity Read ↗

Current Status of Porcine Reproductive and Respiratory Syndrome VaccinesSemantic proximity Read ↗

Recombinant characterization and pathogenicity of a novel L1C RFLP-1-4-4 variant of porcine reproductive and respiratory syndrome virus in China.Semantic proximity Read ↗

Development and immunogenicity evaluation of a quadruple-gene-deleted pseudorabies virus strainSemantic proximity Read ↗

Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequencesSemantic proximity Read ↗

Assessment of African swine fever vaccine candidate ASFV-G-∆MGF in a reversion to virulence studySemantic proximity Read ↗

Porcine Reproductive and Respiratory Syndrome Virus: Immune Escape and Application of Reverse Genetics in Attenuated Live Vaccine DevelopmentSemantic proximity Read ↗

Safety and genetic stability of African swine fever virus vaccine candidate “ASFV-G-∆MGF” in an in vivo “reversion to virulence” studySemantic proximity Read ↗

Re-emerging of porcine respiratory and reproductive syndrome virus (lineage 3) and increased pathogenicity after genomic recombination with vaccine variant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.