Article
Development of a differentiable virus via a spontaneous deletion in the nsp2 region associated with cell adaptation of porcine reproductive and respiratory syndrome virus.
Virus research - 1 Jan 2013
Wang Xiaomin, Sun Lichang, Li Yanhua, Lin Tao, Gao Fei, Yao Huochun, He Kongwang, Tong Guangzhi, Wei Zuzhang, Yuan Shishan
Abstract excerpt
Porcine reproductive and respiratory syndrome virus (PRRSV) is renowned for its genetic, antigenic, and pathogenic heterogeneity. As a consequence, highly pathogenic PRRSV (HP-PRRSV) has emerged and caused tremendous economic losses in the swine industry. In this study, a Chinese HP-PRRSV JX143 isolate was serially passaged in MARC-145 cells up to 100 times. We found that phenotypic changes involved with the cell...
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