Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

Abstract excerpt

Precise control of protein degradation is critical for life, yet how natural genetic variation affects this essential process is largely unknown. Here, we developed a statistically powerful mapping approach to characterize how genetic variation affects protein degradation by the ubiquitin-proteasome system (UPS). Using the yeast Saccharomyces cerevisiae , we systematically mapped genetic influences on the N-end...

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