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Article

Substrate-specific effects of natural genetic variation on proteasome activity.

PLoS genetics - 1 May 2023

Collins Mahlon A, Avery Randi, Albert Frank W

Abstract excerpt

Protein degradation is an essential biological process that regulates protein abundance and removes misfolded and damaged proteins from cells. In eukaryotes, most protein degradation occurs through the stepwise actions of two functionally distinct entities, the ubiquitin system and the proteasome. Ubiquitin system enzymes attach ubiquitin to cellular proteins, targeting them for degradation. The proteasome then...

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Identifiers

PMID: 37126494
DOI: 10.1371/journal.pgen.1010734
PMCID: PMC10174532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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