Article

Mapping the functional importance of site-specific ubiquitination across the human proteome

2025-10-08

Abstract excerpt

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme activation. To date, hundreds of thousands of ubiquitination sites (ubi-sites) have been identified, however fewer than 1% have known functional roles. Here, we assembled a human reference ubiquitinome of 108,341 ubi...

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Literature Corpus work: 77e64860-cfd7-5547-93c1-67257a8c8030
DOI: 10.1101/2025.10.08.681129

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