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Article

Genotype-by-environment interactions shape ubiquitin-proteasome system activity.

Genetics - 12 Nov 2025

Avery Randi R, Collins Mahlon A, Albert Frank W

Abstract excerpt

In genotype-by-environment interactions (GxE), the effect of a genetic variant on a trait depends on the environment. GxE influences numerous organismal traits. However, we have limited understanding of how GxE shapes molecular processes. Here, we characterized how GxE shapes protein degradation, an essential molecular process that affects cellular and organismal physiology. Using 2 isolates of the yeast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40884183
DOI: 10.1093/genetics/iyaf180
PMCID: PMC12606439

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