Article
A proteolytic pathway that recognizes ubiquitin as a degradation signal.
The Journal of biological chemistry - 21 Jul 1995
Johnson E S, Ma P C, Ota I M, Varshavsky A
Abstract excerpt
Previous work has shown that a fusion protein bearing a "nonremovable" N-terminal ubiquitin (Ub) moiety is short-lived in vivo, the fusion's Ub functioning as a degradation signal. The proteolytic system involved, termed the UFD pathway (Ub fusion degradation), was dissected in the yeast Saccharo...
Topics
- Amino Acid Sequence
- Base Sequence
- Fungal Proteins
- Genes, Fungal
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Tetrahydrofolate Dehydrogenase
- Ubiquitin-Conjugating Enzymes
- Ubiquitin-Protein Ligases
- Ubiquitins
- Viral Proteins
- beta-Galactosidase