Article
A proteolytic pathway that recognizes ubiquitin as a degradation signal.
The Journal of biological chemistry - 21 Jul 1995
Johnson E S, Ma P C, Ota I M, Varshavsky A
Abstract excerpt
Previous work has shown that a fusion protein bearing a "nonremovable" N-terminal ubiquitin (Ub) moiety is short-lived in vivo, the fusion's Ub functioning as a degradation signal. The proteolytic system involved, termed the UFD pathway (Ub fusion degradation), was dissected in the yeast Saccharomyces cerevisiae by analyzing mutations that perturb the pathway. Two of the five genes thus identified, UFD1 and UFD5,...
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