Protein Degradation Through Ubiquitination: Insights into the Ubiquitin-Proteasome System Across Biology and Disease

Abstract excerpt

The ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism maintaining cellular proteostasis through the targeted degradation of proteins. Beyond its canonical role in protein turnover, the UPS governs diverse biological processes, including cell cycle control, DNA repair, immune responses, and stress adaptation. Dysregulation of UPS components is increasingly recognized as a driving force in the...

Topics

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• Autophagy in Disease and Therapy
• Cysteine Proteinase Inhibitors
• Drug Discovery
• Endoplasmic Reticulum Stress and Disease
• Musculoskeletal Diseases
• Proteasome Endopeptidase Complex
• Ubiquitin
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

4c6b01dc-0bd9-59e9-8f63-36baddf1f769

DOI

10.20944/preprints202504.2585.v1